Novel biomarker panel predicts prognosis in human papillomavirus-negative oropharyngeal cancer

Human Papillomavirus and Oropharyngeal Cancer

Human papillomavirus: changing paradigms in oropharyngeal cancer.

The human papillomavirus (HPV) has recently been identified as an important etiologic agent in the development of squamous cell carcinoma of the oropharynx. The HPV- associated cancers appear to have a different biology than the HPV-negative cancers, and affect a population that is more likely to be young, male, Caucasian, and nonsmoking. More importantly, however, is the recognition that patie...

Human Papillomavirus Infection and Oropharyngeal Cancer

Squamous cell carcinoma of the head and neck (SCCHN), which affects close to 40,000 individuals each year in the United States, typically involves the oral cavity, oropharynx, hypopharynx, and larynx. Smoking tobacco and alcohol abuse are the major risk factors, and treatment is multidisciplinary, involving the use of chemotherapy, radiation, and surgery. Patients typically present with a sore ...

Oropharyngeal Cancer Epidemic and Human Papillomavirus

A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). Thus, the International Agency for Research against Cancer has acknowledged HPV as a risk factor for OSCC, in addition to smoking and alcohol consumption. Recently, in Finland, the United Kingdom, the Netherlands, the United States, and Sweden, incid...

Human papillomavirus and oropharyngeal cancer in Greenland in 1994–2010

BACKGROUND Oropharyngeal squamous cell carcinoma (OPSCC) is associated with the sexually transmitted human papillomavirus (HPV), smoking and alcohol. In Greenland, a high rate of HPV-induced cervical cancer and venereal diseases are found, which exposes the population for high risk of HPV infection. In Greenland, only girls are included in the mandatory HPV vaccination program. OBJECTIVE To i...